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Poultry

Tributyrin represents a critical advancement in gut health management.

As poultry farming continues to transition toward antibiotic-free systems, maintaining gut health has become a growing challenge.

The removal of antibiotics has led to increased issues such as dysbiosis, leaky gut, and enteric diseases, particularly during the early days of a chick’s life—a critical window for gut development and immune system establishment.

Several factors contribute to poor gut health in modern poultry systems. Feed ingredients contaminated with mycotoxins or anti-nutritional compounds can damage the intestinal lining and trigger chronic inflammation. Infections such as Clostridium perfringens and the growing resistance to anticoccidial drugs further aggravate the situation by compromising gut tissue and encouraging pathogenic growth. Environmental stressors like heat, overcrowding, transport, and feed transitions weaken the birds' natural defenses. In addition, rapid flock turnover creates instability, reducing the time for recovery and adaptation, which leaves birds more vulnerable to gut-related illnesses.

To address these challenges, nutritionists and poultry health experts are increasingly turning to biotic-based strategies. Among them, postbiotics, and in particular tributyrin, have emerged as a powerful tool for supporting gut health without the need for antibiotics. Tributyrin is a stable form of butyric acid that delivers direct benefits to the intestinal tract. It reaches the lower gut, where it plays a crucial role in strengthening the gut wall, reducing inflammation, and suppressing the growth of harmful bacteria by lowering intestinal pH. Unlike raw butyric acid, tributyrin has no offensive odor and is more effective thanks to its targeted delivery and greater stability during feed processing.

Tributyrin also enhances nutrient absorption and feed efficiency, supporting better weight gain and overall bird performance. Its unique ability to provide energy to intestinal cells while modulating the immune response makes it a valuable component in antibiotic-free poultry systems. When used alongside other biotics—such as prebiotics that feed beneficial bacteria and probiotics that introduce competitive microbes-tributyrin helps restore microbial balance and repair gut integrity from multiple angles.

The benefits of tributyrin are significantly enhanced when paired with Gastrointestinal Environment Harmonization (GEH) technology. GEH ensures controlled release and targeted action within specific regions of the gut, increasing the effectiveness of tributyrin while also protecting other biotic components through feed processing and digestion.

As the poultry industry continues to pursue sustainable and profitable production, tributyrin represents a critical advancement in gut health management. Its ability to reinforce the gut barrier, reduce inflammation, and improve performance-all without antibiotics-makes it an essential solution for modern poultry nutrition strategies focused on bird welfare, productivity, and long-term viability.

Good feed transitions support uniform growth across the flock.

In broiler production, smooth transitions between different feed types are vital for achieving strong flock performance.

Throughout their life, broilers move through different feed rations – typically starter, grower, and finisher. These feed stages also differ in texture, such as mash, crumb, or pellet. Each change is designed to meet the bird’s nutritional needs at every stage of growth.

However, if not managed correctly, these feed changes can negatively affect growth, feed intake, flock uniformity, and even carcass quality. That’s why careful feed transition practices are essential.

To manage transitions properly, introduce new feed gradually. One good approach is to top up the existing feed with the new one so they mix together. This helps birds adapt more easily. When moving from starter to grower feed, it’s not just the nutrient content that changes—feed form usually does too. Offering the first delivery of grower feed in a crumb or mini pellet form can help prevent a drop in feed intake.

Good feed transitions support uniform growth across the flock. They also maintain gut health, water intake, and reduce issues like feed flicking. These benefits contribute to consistent weight gain and better carcass quality.

Close monitoring during feed changes is key. Pay attention to the birds before, during, and after the transition. Look out for any changes in feeding or drinking behaviour. If birds eat less or seem unsettled, the feed form or nutrient density may need adjustment.

In summary, proper feed transition helps ensure broilers grow evenly, stay healthy, and reach their full performance potential. A gradual shift, correct feed form, and good observation can make all the difference in final results. Keeping transitions smooth is a small step that has a big impact on productivity and flock welfare.

Aviagen is investing in local breeding stock production within Saudi Arabia. (Image source: Adobe Stock)

Aviagen is continuing to enhance its supply chain and its ‘global reach, local touch’ strategy by investing in a Grandparent (GP) operation for the production and distribution of Parent Stock (PS) in the Kingdom of Saudi Arabia (KSA)

This is a fully-owned Aviagen investment and the project is currently in the early stages of development.

Aviagen continues to recognise the strategic requirement for local, dedicated supply bases to ensure that Aviagen and all of our customers are best prepared to meet the increasing demand for poultry meat in this important, growing region. This investment will create a regional distribution hub for Aviagen brands, strengthening security of supply, and enhancing our ability to serve customers in KSA from a dedicated supply base within the region.

Saudi Arabia and the wider Gulf region present significant opportunities for the growth of poultry production and consumption. Aviagen is proud to support this development by investing in local breeding stock production within the Kingdom, aligning closely with Saudi Arabia’s Vision 2030 goals. With its strategic location and strong potential for industry growth, Saudi Arabia is an ideal location for this investment, providing access to key neighboring Gulf markets.

Tom Exley, President, Aviagen TMEA commented, “This strategic initiative reflects our ongoing commitment to the region, enabling us to deliver greater value to our customers through enhanced security of supply and tailored customer support. By investing locally, Aviagen is helping to strengthen the poultry industry and contribute to the region’s food security and economic development goals.”

ZIVO Bioscience and top animal health firm launch studies on poultry immune-boosting compounds

ZIVO Bioscience, Inc., a biotech and agtech research company developing immune-boosting compounds from proprietary algal cultures, has announced a new partnership with one of the world’s leading animal health companies

The collaboration focuses on advancing ZIVO’s novel biologics for use in the poultry industry and may expand to other livestock and companion animals in the future.

The companies have signed two agreements to conduct independent studies that will explore the potential of ZIVO’s compounds to support poultry health. The goal is to enhance existing vaccination strategies and help address diseases that continue to affect poultry production.

Expanding poultry protection

The first agreement involves a 42-day challenge study focused on coccidiosis, a common and damaging parasitic disease in poultry. This study aims to confirm earlier positive results from ZIVO’s compound, now used alongside the partner’s vaccine. It will also collect samples to evaluate new performance measures. Findings will support ZIVO’s regulatory process with the USDA’s Center for Veterinary Biologics and help establish a strong business case for commercial use.

The second agreement outlines a study of ZIVO’s compounds using a model for a viral poultry disease that causes high mortality and has no available cure. The virus was chosen for its well-known in vivo model, clear clinical results and short testing timeline. The goal is to confirm the antiviral effects ZIVO has already observed in earlier trials, including reduced severity and spread of low-pathogenic avian influenza. Positive outcomes could lead to broader studies covering more viral diseases.

The collaborating animal health company will fully fund both studies. Researchers will assess how ZIVO’s compounds can shorten the time between vaccination and immunity, protect birds in vulnerable periods, enhance immune response and reduce the impact of diseases that suppress the immune system.

“This collaboration supports our strategy to partner with a major animal health company that brings scientific expertise and R&D infrastructure to advance our innovations to global markets efficiently and at scale,” said John Payne, chairman and CEO of ZIVO Bioscience. “We are aligned with this company on the broad applicability of our immune-modulating technology and its potential to create a disruptive, non-antibiotic therapeutic platform.”

Results from the study showed that SNPs found in the HNMT gene significantly increased carnosine levels in chickens. (Image source: Adobe Stock)

Poultry meat is one of the most sought-after foods worldwide, valued not only for the nutrition it provides, but also for its palatability

Besides being popular for its protein, vitamin and mineral content, poultry meat also contains bioactive compounds, particularly carnosine and anserine that determine its palatability. Both these compounds contribute to the umami taste, known to be a key component of meat flavour, with their quantities primarily being influenced by genetics. Moreover, their levels tend to vary among breeds and are often used to determine meat quality.

Besides breed, the carnosine levels in meat tend to depend on a variety of other factors including muscle fibre type and whether the meat is raw or cooked. Meat from the breast and thigh muscles are usually found packed with carnosine, with concentrations being greater in Korean native chickens and Thai indigenous and hybrid native chickens.
On the other hand, anserine is generally found in the skeletal muscles of chickens, cattle and certain species of fish. Its levels are often higher in breast meat compared to thigh meat, given its function in buffering proton production in breast muscle. Moreover, similar to carnosine, the levels of this compound in meat can be determined by the type of meat and chicken line.

A recent study conducted at Chungnam National University aimed to explore the genetic and environmental factors that affect carnosine and anserine content in meat in Korean native chicken red brown line (KNC-R). Single nucleotide polymorphisms (SNPs) were identified in the histamine-N-methyl transferase (HNMT) and histamine-N-methyl transferase-like (HNMT-like) genes and their association with the carnosine and anserine content was studied.

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods were used to genotype one synonymous SNP (rs29009298C/T) of the HNMT gene. On the other hand, PCR allele competitive extension (PACE) genotyping technology was used to genotype four missense SNPs (rs734406537G/A; rs736514667A/G; rs15881680G/A and rs316765035T/C) of the HNMT gene, and one missense SNP rs737657949A/C of the HNMT-like gene.

Results from the study showed that SNPs found in the HNMT gene significantly increased carnosine levels in chickens. Moreover, breeding methods were also found to influence carnosine content to a great extent, with female chickens showing comparatively higher levels than males.

Two associations could be identified between the genotypes of the synonymous SNP: rs29009298C/T, missense SNP rs736514667A/G of the HNMT gene and the content of carnosine. Given its efficiency and precision, PACE technology was therefore regarded as a useful and reliable tool that could be used for the improvement of livestock systems.

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